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In SUSTAIN 6 the preapproval CVOT for subcutaneous semaglutide the rate of CV death, nonfatal myocardial infarction, or nonfatal stroke was significantly lower among patients receiving semaglutide (6.6% [108/1,648]) than among those receiving placebo (8.9% [146/1,649]
Activating it (or in this case, increasing its expression and signaling capacity) triggers hormone-sensitive lipase, which begins breaking down stored triglycerides into free fatty acids and glycerol
The metabolic adaptations from consistent use appear to persist even with dose reduction in many cases
Best sources of fats to help release GLP-1s: Olive oil (a staple of the Mediterranean diet) Avocados Fatty fish (salmon, sardines, mackerel, arctic char, trout) Nuts and seeds (raw almonds, walnuts, pistachios, whole peanuts, flaxseeds, natural peanut butter, flax seeds, chia seeds, hemp hearts) In fact, a diet high in olive oil increased GLP-1 levels, improved insulin sensitivity, and reduced weight gain in several studies (Bonaruc et al, 2016)
Aoe S, Mio K, Yamanaka C, Kuge T
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